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Simultaneous extraction and determination of four different groups of pharmaceuticals in compost using optimized ultrasonic extraction and ultrahigh pressure liquid chromatography-mass spectrometry

dc.creatorMiguel Angel López Zavala
dc.date2015
dc.date.accessioned2018-10-18T21:51:05Z
dc.date.available2018-10-18T21:51:05Z
dc.identifier.issn219673
dc.identifier.doi10.1016/j.chroma.2015.10.051
dc.identifier.urihttp://hdl.handle.net/11285/630501
dc.descriptionAn analytical method for the simultaneous extraction and determination of four different groups of pharmaceuticals in compost from the biodegradation of biological infectious hazardous wastes (BIHW) was developed and successfully validated. Compost samples were spiked with known concentrations of the pharmaceuticals of interest. Ultrasonic extraction with an ethyl acetate and methanol solution (1:1) resulted to be effective for the extraction of eight target compounds. All the compounds were separated in a single gradient run by UHPLC using a Zorbax SB C18 Agilent (2.1×50mm, 1.8μm) column. Analytes were detected and quantified via multiple reaction monitoring (MRM) using an AB SCIEX API-5000TM triple quadrupole with electrospray ionization (ESI) in positive mode. The optimum mobile phase consisted of ammonium formate (2mM, pH 3): MeOH (50:50). Recovery values of the ultrasonic extraction for all compounds were on the order of 87% to 113% with absolute deviations lower than 11%. The limits of detection and quantification for the eight pharmaceuticals were on the order of 0.66ngg-1 and 2ngg-1 respectively for all the pharmaceuticals analyzed. These values are lower than those values reported in the literature. Suitable level of linearity, acceptable limits of detection and quantification, good repeatability and inter-day precision, non-ion interference, and low matrix effect resulted from the validation of the analytical method. Implementation of the analytical procedure proposed in this research will contribute in having shorter analysis time and lower costs when working with complex matrices such as compost. © 2015 The Authors.
dc.languageeng
dc.publisherElsevier
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84947783933&doi=10.1016%2fj.chroma.2015.10.051&partnerID=40&md5=2ce009e271ea1df48d91189fea987273
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceJournal of Chromatography A
dc.subjectBiodegradation
dc.subjectBiohazards
dc.subjectDrug products
dc.subjectElectrospray ionization
dc.subjectExtraction
dc.subjectLiquid chromatography
dc.subjectMass spectrometry
dc.subjectSonochemistry
dc.subjectUltrasonic applications
dc.subjectAbsolute deviations
dc.subjectAnalytical procedure
dc.subjectElectrospray ionization (ESI)
dc.subjectMultiple reaction monitoring
dc.subjectSimultaneous extractions
dc.subjectU-HPLC-MS
dc.subjectUltra-high-pressure liquid chromatography
dc.subjectUltrasonic extraction
dc.subjectComposting
dc.subjectacetic acid ethyl ester
dc.subjectammonium formate
dc.subjectantiinflammatory agent
dc.subjectantineoplastic agent
dc.subjectatenolol
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectciprofloxacin
dc.subjectcyclophosphamide
dc.subjectifosfamide
dc.subjectketorolac
dc.subjectmethanol
dc.subjectnaproxen
dc.subjectofloxacin
dc.subjectpropranolol
dc.subjectquinoline derived antiinfective agent
dc.subjectdrug
dc.subjectsoil
dc.subjectanalysis time
dc.subjectanalytical parameters
dc.subjectArticle
dc.subjectchromatography by mobile phase
dc.subjectcompost
dc.subjectdrug determination
dc.subjectelectrospray
dc.subjectextraction
dc.subjecthazardous waste
dc.subjectlimit of detection
dc.subjectlimit of quantitation
dc.subjectmass spectrometry
dc.subjectmatrix effect
dc.subjectmeasurement precision
dc.subjectmeasurement repeatability
dc.subjectMexico
dc.subjectnon ion interference
dc.subjectpriority journal
dc.subjectprocess development
dc.subjectprocess optimization
dc.subjectultra performance liquid chromatography
dc.subjectultrasonic extraction
dc.subjectvalidation study
dc.subjectchemical analysis
dc.subjectchemistry
dc.subjecthigh performance liquid chromatography
dc.subjectprocedures
dc.subjectreproducibility
dc.subjectsoil
dc.subjectultrasound
dc.subjectChemistry Techniques, Analytical
dc.subjectChromatography, High Pressure Liquid
dc.subjectLimit of Detection
dc.subjectMass Spectrometry
dc.subjectPharmaceutical Preparations
dc.subjectReproducibility of Results
dc.subjectSoil
dc.subjectUltrasonics
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleSimultaneous extraction and determination of four different groups of pharmaceuticals in compost using optimized ultrasonic extraction and ultrahigh pressure liquid chromatography-mass spectrometry
dc.typeArtículo
dc.identifier.volume1423
dc.identifier.startpage9
dc.identifier.endpage18
refterms.dateFOA2018-10-18T21:51:05Z


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