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Shorter men live longer: Association of height with longevity and FOXO3 genotype in American men of Japanese ancestry

dc.contributor.authorRodríguez Martínez, Beatriz Lorenza
dc.creatorBEATRIZ LORENZA RODRIGUEZ MARTINEZ;699725
dc.creatorBEATRIZ LORENZA RODRIGUEZ MARTINEZ;699725es
dc.date2014
dc.date.accessioned2018-10-18T21:22:00Z
dc.date.available2018-10-18T21:22:00Z
dc.identifier.issn19326203
dc.identifier.doi10.1371/journal.pone.0094385
dc.identifier.urihttp://hdl.handle.net/11285/630454
dc.descriptionObjectives: To determine the relation between height, FOXO3 genotype and age of death in humans. Methods: Observational study of 8,003 American men of Japanese ancestry from the Honolulu Heart Program/Honolulu-Asia Aging Study (HHP/HAAS), a genetically and culturally homogeneous cohort followed for over 40 years. A Cox regression model with age as the time scale, stratified by year of birth, was used to estimate the effect of baseline height on mortality during follow-up. An analysis of height and longevity-associated variants of the key regulatory gene in the insulin/IGF-1 signaling (IIS) pathway, FOXO3, was performed in a HHP-HAAS subpopulation. A study of fasting insulin level and height was conducted in another HHP-HAAS subpopulation. Results: A positive association was found between baseline height and all-cause mortality (RR = 1.007; 95% CI 1.003-1.011; P = 0.002) over the follow-up period. Adjustments for possible confounding variables reduced this association only slightly (RR = 1.006; 95% CI 1.002-1.010; P = 0.007). In addition, height was positively associated with all cancer mortality and mortality from cancer unrelated to smoking. A Cox regression model with time-dependent covariates showed that relative risk for baseline height on mortality increased as the population aged. Comparison of genotypes of a longevity-associated single nucleotide polymorphism in FOXO3 showed that the longevity allele was inversely associated with height. This finding was consistent with prior findings in model organisms of aging. Height was also positively associated with fasting blood insulin level, a risk factor for mortality. Regression analysis of fasting insulin level (mIU/L) on height (cm) adjusting for the age both data were collected yielded a regression coefficient of 0.26 (95% CI 0.10-0.42; P = 0.001). Conclusion: Height in mid-life is positively associated with mortality, with shorter stature predicting longer lifespan. Height was, moreover, associated with fasting insulin level and the longevity genotype of FOXO3, consistent with a mechanistic role for the IIS pathway. © 2014 He et al.
dc.languageeng
dc.publisherPublic Library of Science
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84900533842&doi=10.1371%2fjournal.pone.0094385&partnerID=40&md5=3a320fdc66b4cb56d8de78d342b52db6
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePLoS ONE
dc.subjectinsulin
dc.subjectsomatomedin C
dc.subjecttranscription factor FKHRL1
dc.subjectforkhead transcription factor
dc.subjectFOXO3 protein, human
dc.subjectinsulin
dc.subjectadult
dc.subjectage
dc.subjectage of death
dc.subjectaged
dc.subjectarticle
dc.subjectAsian American
dc.subjectbody height
dc.subjectcancer mortality
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectfollow up
dc.subjectFOXO3 gene
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjecthuman
dc.subjectinsulin blood level
dc.subjectlife expectancy
dc.subjectlongevity
dc.subjectmale
dc.subjectobservational study
dc.subjectpopulation research
dc.subjectprospective study
dc.subjectregulator gene
dc.subjectrisk factor
dc.subjectsignal transduction
dc.subjectsingle nucleotide polymorphism
dc.subjectsmoking
dc.subjectAsian American
dc.subjectblood
dc.subjectbody height
dc.subjectdiet restriction
dc.subjectgenetics
dc.subjectlongevity
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectproportional hazards model
dc.subjectstatistics and numerical data
dc.subjectAged
dc.subjectAsian Americans
dc.subjectBody Height
dc.subjectFasting
dc.subjectForkhead Transcription Factors
dc.subjectGenotype
dc.subjectHumans
dc.subjectInsulin
dc.subjectLongevity
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProportional Hazards Models
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleShorter men live longer: Association of height with longevity and FOXO3 genotype in American men of Japanese ancestry
dc.typeArtículo
dc.identifier.volume9
dc.identifier.issue5
refterms.dateFOA2018-10-18T21:22:00Z


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