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Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response

dc.creatorMaría Teresa González Garza y Barrón
dc.creatorJorge Eugenio Moreno Cuevas
dc.date2015
dc.date.accessioned2018-10-18T20:34:51Z
dc.date.available2018-10-18T20:34:51Z
dc.identifier.issn20908040
dc.identifier.doi10.1155/2015/943497
dc.identifier.urihttp://hdl.handle.net/11285/630375
dc.descriptionInflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a target to reduce liver fibrosis. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. The aim of this review is to describe the role of inflammation and the immune response in the pathogenesis of liver fibrosis and detail the mechanisms of inhibition of both events by medicinal plants in order to reduce liver fibrosis. Copyright © 2015 Florent Duval et al.
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928036904&doi=10.1155%2f2015%2f943497&partnerID=40&md5=71e5eb3938a4797d154533d52a4860cc
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceInternational Journal of Inflammation
dc.subjectandrographolide
dc.subjectantifibrotic agent
dc.subjectantiinflammatory agent
dc.subjectbaicalin
dc.subjectberberine
dc.subjectcaffeine
dc.subjectchemokine
dc.subjectchlorogenic acid
dc.subjectcurcumin
dc.subjectcytokine
dc.subjectEmblica officinalis extract
dc.subjectGinkgo biloba extract
dc.subjectginsenoside Rd
dc.subjectginsenoside Rg 1
dc.subjectginsenoside Rg 3
dc.subjectglycyrrhizic acid
dc.subjectherbaceous agent
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectkutkin
dc.subjectnicotinic acid
dc.subjectPhyllanthus amarus extract
dc.subjectPhyllanthus rheedi extract
dc.subjectPhyllanthus urinaria koreanis extract
dc.subjectplant extract
dc.subjectpyrazinoic acid
dc.subjectsalvianolic acid A
dc.subjectsilymarin
dc.subjectsodium tanshinone IIA
dc.subjecttanshinone IIA
dc.subjectunclassified drug
dc.subjectunindexed drug
dc.subjectAndrographis paniculata
dc.subjectantiinflammatory activity
dc.subjectArticle
dc.subjectBerberis aristata
dc.subjectBupleurum
dc.subjectBupleurum falcatum
dc.subjectCD4+ T lymphocyte
dc.subjectCD8+ T lymphocyte
dc.subjectcoffee
dc.subjectCurcuma longa
dc.subjectdrug mechanism
dc.subjectdrug targeting
dc.subjectGinkgo biloba
dc.subjectginseng
dc.subjectGlycyrrhiza glabra
dc.subjecthuman
dc.subjectimmune response
dc.subjectinflammation
dc.subjectliver fibrosis
dc.subjectliver protection
dc.subjectmacrophage
dc.subjectmast cell
dc.subjectmedicinal plant
dc.subjectnatural killer cell
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectPhyllanthus
dc.subjectPicrorhiza kurroa
dc.subjectpriority journal
dc.subjectSalvia miltiorrhiza
dc.subjectScutellaria baicalensis
dc.subjectSilybum marianum
dc.subjectstellate cell
dc.subjectthrombocyte
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleLiver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response
dc.typeArtículo
dc.identifier.volume2015
refterms.dateFOA2018-10-18T20:34:51Z


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