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Biotransformation of Indole to 3-Methylindole by Lysinibacillus xylanilyticus Strain MA

dc.creatorASHUTOSH SHARMA;398262
dc.creatorASHUTOSH SHARMA;398262es
dc.date2015
dc.date.accessioned2018-10-18T20:12:47Z
dc.date.available2018-10-18T20:12:47Z
dc.identifier.issn20909063
dc.identifier.doi10.1155/2015/425329
dc.identifier.urihttp://hdl.handle.net/11285/630290
dc.descriptionAn indole-biotransforming strain MA was identified as Lysinibacillus xylanilyticus on the basis of the 16S rRNA gene sequencing. It transforms indole completely from the broth culture in the presence of an additional carbon source (i.e., sodium succinate). Gas-chromatography-mass spectrometry identified indole-3-acetamide, indole-3-acetic acid, and 3-methylindole as transformation products. Tryptophan-2-monooxygenase activity was detected in the crude extracts of indole-induced cells of strain MA, which confirms the formation of indole-3-acetamide from tryptophan in the degradation pathway of indole. On the basis of identified metabolites and enzyme assay, we have proposed a new transformation pathway for indole degradation. Indole was first transformed to indole-3-acetamide via tryptophan. Indole-3-acetamide was then transformed to indole-3-acetic acid that was decarboxylated to 3-methylindole. This is the first report of a 3-methylindole synthesis via the degradation pathway of indole. © 2015 Pankaj Kumar Arora et al.
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84936792145&doi=10.1155%2f2015%2f425329&partnerID=40&md5=f65149ec0263a0fc2d3f87cb6d3b22d4
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceJournal of Chemistry
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleBiotransformation of Indole to 3-Methylindole by Lysinibacillus xylanilyticus Strain MA
dc.typeArtículo
dc.identifier.volume2015
refterms.dateFOA2018-10-18T20:12:47Z


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