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Metformin-related lactic acidosis: Case report [Acidosis láctica por metformina: reporte de caso]

dc.creatorJorge Samuel Cortés Román
dc.date2017
dc.date.accessioned2018-10-19T13:37:40Z
dc.date.available2018-10-19T13:37:40Z
dc.identifier.issn1203347
dc.identifier.doi10.1016/j.rca.2017.07.009
dc.identifier.urihttp://hdl.handle.net/11285/630637
dc.descriptionLactic acidosis is defined as the presence of pH < 7.35, blood lactate> 2.0 mmol/L and PaCO2 < 42 mmHg. However, the definition of severe lactic acidosis is controversial. The primary cause of severe lactic acidosis is shock. Although rare, metformin-related lactic acidosis is associated with a mortality as high as 50%. The treatment for metabolic acidosis, including lactic acidosis, may be specific or general, using sodium bicarbonate, trihydroxyaminomethane, carbicarb or continuous haemodiafiltration. The successful treatment of lactic acidosis depends on the control of the aetiological source. Intermittent or continuous renal replacement therapy is perfectly justified, shock being the argument for deciding which modality to use. We report a case of a male patient presenting with metformin poisoning as a result of attempted suicide, who developed lactic acidosis and multiple organ failure. The critical success factor was treatment with continuous haemodiafiltration. © 2017 Sociedad Colombiana de Anestesiología y Reanimación
dc.languageeng
dc.languagespa
dc.publisherElsevier Doyma
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85029865423&doi=10.1016%2fj.rca.2017.07.009&partnerID=40&md5=ac79c0e7a5771162d07f91bf551ffa3f
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceRevista Colombiana de Anestesiologia
dc.subjectmetformin
dc.subjectArticle
dc.subjectcase report
dc.subjectclinical article
dc.subjecthuman
dc.subjectlactic acidosis
dc.subjectmale
dc.subjectmultiple organ failure
dc.subjectsuicide attempt
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleMetformin-related lactic acidosis: Case report [Acidosis láctica por metformina: reporte de caso]
dc.typeArtículo
dc.identifier.volume45
dc.identifier.issue4
dc.identifier.startpage353
dc.identifier.endpage359
refterms.dateFOA2018-10-19T13:37:40Z


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