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Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat

dc.creatorAlexandro José Martagón Rosado
dc.date2015
dc.date.accessioned2018-10-18T21:51:05Z
dc.date.available2018-10-18T21:51:05Z
dc.identifier.issn22111247
dc.identifier.doi10.1016/j.celrep.2015.10.022
dc.identifier.urihttp://hdl.handle.net/11285/630499
dc.descriptionThe functional conversion of white adipose tissue (WAT) into a tissue with brown adipose tissue (BAT)-like activity, often referred to as "browning," represents an intriguing strategy for combating obesity and metabolic disease. We demonstrate that thyroid hormone receptor (TR) activation by a synthetic agonist markedly induces a program of adaptive thermogenesis in subcutaneous WAT that coincides with a restoration of cold tolerance to cold-intolerant mice. Distinct from most other browning agents, pharmacological TR activation dissociates the browning of WAT from activation of classical BAT. TR agonism also induces the browning of white adipocytes in vitro, indicating that TR-mediated browning is cell autonomous. These data establish TR agonists as a class of browning agents, implicate the TRs in the browning of WAT, and suggest a profound pharmacological potential of this action. © 2015 The Authors.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84952871381&doi=10.1016%2fj.celrep.2015.10.022&partnerID=40&md5=fcbbbcc866575818ec8b54cf5d46aad9
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceCell Reports
dc.subjecteprotirome
dc.subjecthormone receptor stimulating agent
dc.subjectpropranolol
dc.subjectsobetirome
dc.subjectthyroid hormone receptor
dc.subjectthyroid hormone receptor agonist
dc.subjectunclassified drug
dc.subjectthyroid hormone receptor
dc.subjectadipocyte
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrown adipose tissue
dc.subjectcold tolerance
dc.subjectcontrolled study
dc.subjectin vitro study
dc.subjectmale
dc.subjectmetabolic disorder
dc.subjectmouse
dc.subjectnonhuman
dc.subjectobesity
dc.subjectpharmacological procedures
dc.subjectpriority journal
dc.subjectreceptor blocking
dc.subjectsubcutaneous fat
dc.subjectthermogenesis
dc.subjectwhite adipose tissue
dc.subjectanimal
dc.subjectbrown adipocyte
dc.subjectbrown adipose tissue
dc.subjectC57BL mouse
dc.subjectenergy metabolism
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectwhite adipocyte
dc.subjectwhite adipose tissue
dc.subjectAdipocytes, Brown
dc.subjectAdipocytes, White
dc.subjectAdipose Tissue, Brown
dc.subjectAdipose Tissue, White
dc.subjectAnimals
dc.subjectEnergy Metabolism
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectObesity
dc.subjectReceptors, Thyroid Hormone
dc.subjectThermogenesis
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titlePharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat
dc.typeArtículo
dc.identifier.volume13
dc.identifier.issue8
dc.identifier.startpage1528
dc.identifier.endpage1537
refterms.dateFOA2018-10-18T21:51:05Z


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