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dc.creatorGuillermo Torre Amione
dc.date2014
dc.date.accessioned2018-10-18T20:34:56Z
dc.date.available2018-10-18T20:34:56Z
dc.identifier.issn7351097
dc.identifier.doi10.1016/j.jacc.2014.06.1188
dc.identifier.urihttp://hdl.handle.net/11285/630400
dc.descriptionBACKGROUND: Hemodynamics assessment is important for detecting and treating post-implant residual heart failure, but its accuracy is unverified in patients with continuous-flow left ventricular assist devices (CF-LVADs).OBJECTIVES: We determined whether Doppler and 2-dimensional transthoracic echocardiography reliably assess hemodynamics in patients supported with CF-LVADs.METHODS: Simultaneous echocardiography and right heart catheterization were prospectively performed in 50 consecutive patients supported by using the HeartMate II CF-LVAD at baseline pump speeds. The first 40 patients were assessed to determine the accuracy of Doppler and 2-dimensional echocardiography parameters to estimate hemodynamics and to derive a diagnostic algorithm for discrimination between mean pulmonary capillary wedge pressure ≤15 versus >15 mm Hg. Ten patients served as a validation cohort.RESULTS: Doppler echocardiographic and invasive measures of mean right atrial pressure (RAP) (r = 0.863; p < 0.0001), systolic pulmonary artery pressure (sPAP) (r=0.880; p<0.0001), right ventricular outflowtract stroke volume (r=0.660; p < 0.0001), and pulmonary vascular resistance (r = 0.643; p = 0.001) correlated significantly. Several parameters, including mitral ratio of the early to late ventricular filling velocities >2, RAP >10 mm Hg, sPAP >40 mm Hg, left atrial volume index >33 ml/m2, ratio of mitral inflow early diastolic filling peak velocity to early diastolic mitral annular velocity >14, and pulmonary vascular resistance >2.5 Wood units, accurately identified patients with pulmonary capillary wedge pressure >15 mm Hg (area under the curve: 0.73 to 0.98). An algorithm integrating mitral inflow velocities, RAP, sPAP, and left atrial volume index was90%accurate in distinguishing normal from elevated left ventricular filling pressures.CONCLUSIONS: Doppler echocardiography accurately estimated intracardiac hemodynamics in these patients supported with CF-LVAD. Our algorithm reliably distinguished normal from elevated left ventricular filling pressures. © 2014 by the American College of Cardiology Foundation.
dc.languageeng
dc.publisherElsevier USA
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84908030072&doi=10.1016%2fj.jacc.2014.06.1188&partnerID=40&md5=de4f3f2f3938ac7d93b54275fe95e4a1
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceJournal of the American College of Cardiology
dc.subjectadult
dc.subjectArticle
dc.subjectclinical article
dc.subjectcontinuous flow left ventricular assist device
dc.subjectDoppler echocardiography
dc.subjectechocardiography
dc.subjectfemale
dc.subjectheart catheterization
dc.subjectheart hemodynamics
dc.subjectheart left ventricle filling
dc.subjectheart right atrium pressure
dc.subjectheart right ventricle outflow tract
dc.subjectheart stroke volume
dc.subjecthuman
dc.subjectlung artery pressure
dc.subjectlung vascular resistance
dc.subjectmale
dc.subjectpulmonary artery occlusion pressure
dc.subjectsystolic heart failure
dc.subjecttransthoracic echocardiography
dc.subjectaged
dc.subjectechography
dc.subjectevaluation study
dc.subjectheart assist device
dc.subjectHeart Failure, Systolic
dc.subjectheart left ventricle function
dc.subjecthemodynamics
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectprocedures
dc.subjectprospective study
dc.subjectAdult
dc.subjectAged
dc.subjectCardiac Catheterization
dc.subjectEchocardiography, Doppler
dc.subjectFemale
dc.subjectHeart Failure, Systolic
dc.subjectHeart-Assist Devices
dc.subjectHemodynamics
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectProspective Studies
dc.subjectVentricular Function, Left
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleEchocardiographic evaluation of hemodynamics in patients with systolic heart failure supported by a continuous-flow LVAD
dc.typeArtículo
dc.identifier.volume64
dc.identifier.issue12
dc.identifier.startpage1231
dc.identifier.endpage1241
refterms.dateFOA2018-10-18T20:34:56Z


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