dc.creator | Guillermo Torre Amione | |
dc.date | 2014 | |
dc.date.accessioned | 2018-10-18T20:34:56Z | |
dc.date.available | 2018-10-18T20:34:56Z | |
dc.identifier.issn | 7351097 | |
dc.identifier.doi | 10.1016/j.jacc.2014.06.1188 | |
dc.identifier.uri | http://hdl.handle.net/11285/630400 | |
dc.description | BACKGROUND: Hemodynamics assessment is important for detecting and treating post-implant residual heart failure, but its accuracy is unverified in patients with continuous-flow left ventricular assist devices (CF-LVADs).OBJECTIVES: We determined whether Doppler and 2-dimensional transthoracic echocardiography reliably assess hemodynamics in patients supported with CF-LVADs.METHODS: Simultaneous echocardiography and right heart catheterization were prospectively performed in 50 consecutive patients supported by using the HeartMate II CF-LVAD at baseline pump speeds. The first 40 patients were assessed to determine the accuracy of Doppler and 2-dimensional echocardiography parameters to estimate hemodynamics and to derive a diagnostic algorithm for discrimination between mean pulmonary capillary wedge pressure ≤15 versus >15 mm Hg. Ten patients served as a validation cohort.RESULTS: Doppler echocardiographic and invasive measures of mean right atrial pressure (RAP) (r = 0.863; p < 0.0001), systolic pulmonary artery pressure (sPAP) (r=0.880; p<0.0001), right ventricular outflowtract stroke volume (r=0.660; p < 0.0001), and pulmonary vascular resistance (r = 0.643; p = 0.001) correlated significantly. Several parameters, including mitral ratio of the early to late ventricular filling velocities >2, RAP >10 mm Hg, sPAP >40 mm Hg, left atrial volume index >33 ml/m2, ratio of mitral inflow early diastolic filling peak velocity to early diastolic mitral annular velocity >14, and pulmonary vascular resistance >2.5 Wood units, accurately identified patients with pulmonary capillary wedge pressure >15 mm Hg (area under the curve: 0.73 to 0.98). An algorithm integrating mitral inflow velocities, RAP, sPAP, and left atrial volume index was90%accurate in distinguishing normal from elevated left ventricular filling pressures.CONCLUSIONS: Doppler echocardiography accurately estimated intracardiac hemodynamics in these patients supported with CF-LVAD. Our algorithm reliably distinguished normal from elevated left ventricular filling pressures. © 2014 by the American College of Cardiology Foundation. | |
dc.language | eng | |
dc.publisher | Elsevier USA | |
dc.relation | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908030072&doi=10.1016%2fj.jacc.2014.06.1188&partnerID=40&md5=de4f3f2f3938ac7d93b54275fe95e4a1 | |
dc.relation | Investigadores | |
dc.relation | Estudiantes | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.source | Journal of the American College of Cardiology | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | clinical article | |
dc.subject | continuous flow left ventricular assist device | |
dc.subject | Doppler echocardiography | |
dc.subject | echocardiography | |
dc.subject | female | |
dc.subject | heart catheterization | |
dc.subject | heart hemodynamics | |
dc.subject | heart left ventricle filling | |
dc.subject | heart right atrium pressure | |
dc.subject | heart right ventricle outflow tract | |
dc.subject | heart stroke volume | |
dc.subject | human | |
dc.subject | lung artery pressure | |
dc.subject | lung vascular resistance | |
dc.subject | male | |
dc.subject | pulmonary artery occlusion pressure | |
dc.subject | systolic heart failure | |
dc.subject | transthoracic echocardiography | |
dc.subject | aged | |
dc.subject | echography | |
dc.subject | evaluation study | |
dc.subject | heart assist device | |
dc.subject | Heart Failure, Systolic | |
dc.subject | heart left ventricle function | |
dc.subject | hemodynamics | |
dc.subject | middle aged | |
dc.subject | physiology | |
dc.subject | procedures | |
dc.subject | prospective study | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Cardiac Catheterization | |
dc.subject | Echocardiography, Doppler | |
dc.subject | Female | |
dc.subject | Heart Failure, Systolic | |
dc.subject | Heart-Assist Devices | |
dc.subject | Hemodynamics | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prospective Studies | |
dc.subject | Ventricular Function, Left | |
dc.subject.classification | 7 INGENIERÍA Y TECNOLOGÍA | |
dc.title | Echocardiographic evaluation of hemodynamics in patients with systolic heart failure supported by a continuous-flow LVAD | |
dc.type | Artículo | |
dc.identifier.volume | 64 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1231 | |
dc.identifier.endpage | 1241 | |
refterms.dateFOA | 2018-10-18T20:34:56Z | |