dc.creator | Eduardo Alejandro Reyes Serratos | |
dc.date | 2015 | |
dc.date.accessioned | 2018-10-19T14:22:17Z | |
dc.date.available | 2018-10-19T14:22:17Z | |
dc.identifier.issn | 23146133 | |
dc.identifier.doi | 10.1155/2015/285491 | |
dc.identifier.uri | http://hdl.handle.net/11285/630675 | |
dc.description | The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly- phenotype. Subjects with PPARG2 Ala- phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased. © 2015 Mónica Vázquez-Del Mercado et al. | |
dc.language | eng | |
dc.publisher | Hindawi Limited | |
dc.relation | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936745574&doi=10.1155%2f2015%2f285491&partnerID=40&md5=695556a018bba0f549dd4470d85496c8 | |
dc.relation | Investigadores | |
dc.relation | Estudiantes | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.source | BioMed Research International | |
dc.subject | adipocytokine | |
dc.subject | apolipoprotein A1 | |
dc.subject | apolipoprotein B | |
dc.subject | glucose | |
dc.subject | high density lipoprotein cholesterol | |
dc.subject | insulin | |
dc.subject | leptin | |
dc.subject | low density lipoprotein cholesterol | |
dc.subject | peroxisome proliferator activated receptor gamma 2 | |
dc.subject | peroxisome proliferator activated receptor gamma coactivator 1alpha | |
dc.subject | resistin | |
dc.subject | triacylglycerol | |
dc.subject | very low density lipoprotein cholesterol | |
dc.subject | genetic marker | |
dc.subject | peroxisome proliferator activated receptor gamma | |
dc.subject | peroxisome proliferator activated receptor gamma coactivator 1alpha | |
dc.subject | PPARGC1A protein, human | |
dc.subject | transcription factor | |
dc.subject | abdominal obesity | |
dc.subject | adipogenesis | |
dc.subject | adult | |
dc.subject | allele | |
dc.subject | Article | |
dc.subject | body fat | |
dc.subject | body mass | |
dc.subject | controlled study | |
dc.subject | dyslipidemia | |
dc.subject | female | |
dc.subject | genetic polymorphism | |
dc.subject | genetic risk | |
dc.subject | glucose metabolism | |
dc.subject | hip circumference | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | Mestizo | |
dc.subject | Mexican | |
dc.subject | obesity | |
dc.subject | phenotype | |
dc.subject | polymerase chain reaction | |
dc.subject | restriction fragment length polymorphism | |
dc.subject | waist circumference | |
dc.subject | age distribution | |
dc.subject | aged | |
dc.subject | allele | |
dc.subject | ethnology | |
dc.subject | genetic association study | |
dc.subject | genetic marker | |
dc.subject | genetic predisposition | |
dc.subject | genetics | |
dc.subject | incidence | |
dc.subject | Metabolic Diseases | |
dc.subject | Mexico | |
dc.subject | middle aged | |
dc.subject | obesity | |
dc.subject | risk factor | |
dc.subject | sex ratio | |
dc.subject | single nucleotide polymorphism | |
dc.subject | very elderly | |
dc.subject | young adult | |
dc.subject | Adult | |
dc.subject | Age Distribution | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Alleles | |
dc.subject | Female | |
dc.subject | Genetic Association Studies | |
dc.subject | Genetic Markers | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Humans | |
dc.subject | Incidence | |
dc.subject | Male | |
dc.subject | Metabolic Diseases | |
dc.subject | Mexico | |
dc.subject | Middle Aged | |
dc.subject | Obesity | |
dc.subject | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | PPAR gamma | |
dc.subject | Risk Factors | |
dc.subject | Sex Distribution | |
dc.subject | Transcription Factors | |
dc.subject | Young Adult | |
dc.subject.classification | 7 INGENIERÍA Y TECNOLOGÍA | |
dc.title | The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors even Obesity in a Mexican-Mestizo Population | |
dc.type | Artículo | |
dc.identifier.volume | 2015 | |
refterms.dateFOA | 2018-10-19T14:22:17Z | |