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dc.creatorEduardo Alejandro Reyes Serratos
dc.date2015
dc.date.accessioned2018-10-19T14:22:17Z
dc.date.available2018-10-19T14:22:17Z
dc.identifier.issn23146133
dc.identifier.doi10.1155/2015/285491
dc.identifier.urihttp://hdl.handle.net/11285/630675
dc.descriptionThe aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly- phenotype. Subjects with PPARG2 Ala- phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased. © 2015 Mónica Vázquez-Del Mercado et al.
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84936745574&doi=10.1155%2f2015%2f285491&partnerID=40&md5=695556a018bba0f549dd4470d85496c8
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBioMed Research International
dc.subjectadipocytokine
dc.subjectapolipoprotein A1
dc.subjectapolipoprotein B
dc.subjectglucose
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjectleptin
dc.subjectlow density lipoprotein cholesterol
dc.subjectperoxisome proliferator activated receptor gamma 2
dc.subjectperoxisome proliferator activated receptor gamma coactivator 1alpha
dc.subjectresistin
dc.subjecttriacylglycerol
dc.subjectvery low density lipoprotein cholesterol
dc.subjectgenetic marker
dc.subjectperoxisome proliferator activated receptor gamma
dc.subjectperoxisome proliferator activated receptor gamma coactivator 1alpha
dc.subjectPPARGC1A protein, human
dc.subjecttranscription factor
dc.subjectabdominal obesity
dc.subjectadipogenesis
dc.subjectadult
dc.subjectallele
dc.subjectArticle
dc.subjectbody fat
dc.subjectbody mass
dc.subjectcontrolled study
dc.subjectdyslipidemia
dc.subjectfemale
dc.subjectgenetic polymorphism
dc.subjectgenetic risk
dc.subjectglucose metabolism
dc.subjecthip circumference
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectMestizo
dc.subjectMexican
dc.subjectobesity
dc.subjectphenotype
dc.subjectpolymerase chain reaction
dc.subjectrestriction fragment length polymorphism
dc.subjectwaist circumference
dc.subjectage distribution
dc.subjectaged
dc.subjectallele
dc.subjectethnology
dc.subjectgenetic association study
dc.subjectgenetic marker
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectincidence
dc.subjectMetabolic Diseases
dc.subjectMexico
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectrisk factor
dc.subjectsex ratio
dc.subjectsingle nucleotide polymorphism
dc.subjectvery elderly
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAge Distribution
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlleles
dc.subjectFemale
dc.subjectGenetic Association Studies
dc.subjectGenetic Markers
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMetabolic Diseases
dc.subjectMexico
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPPAR gamma
dc.subjectRisk Factors
dc.subjectSex Distribution
dc.subjectTranscription Factors
dc.subjectYoung Adult
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleThe 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors even Obesity in a Mexican-Mestizo Population
dc.typeArtículo
dc.identifier.volume2015
refterms.dateFOA2018-10-19T14:22:17Z


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