Exosome-like vesicles in intercellular communication: Investigating the role of exosomal proteins in the pathophysiology of obesity and exploring the potential therapeutic use of exosomes.

dc.audience.educationlevelPúblico en general/General publices_MX
dc.contributor.advisorGonzález Valdez, José Guillermo
dc.contributor.authorDonoso Quezada, Javier Alejandro
dc.contributor.catalogerpuemcuervo, emipsanchezes_MX
dc.contributor.committeememberRamos Parra, Perla Azucena
dc.contributor.committeememberGenevieve Brunck, Marion Emilie
dc.contributor.committeememberChávez Santoscoy, Rocío Alejandra
dc.contributor.committeememberGómez Loredo, Alma Elizabeth
dc.contributor.departmentEscuela de Ingeniería y Cienciases_MX
dc.contributor.institutionCampus Monterreyes_MX
dc.contributor.mentorBrix Pedersen, Susanne
dc.creatorGONZALEZ VALDEZ, JOSE GUILLERMO; 234501
dc.date.accepted2023-06-15
dc.date.accessioned2024-03-14T00:56:23Z
dc.date.available2024-03-14T00:56:23Z
dc.date.issued2023-06-15
dc.descriptionhttps://orcid.org/0000-0001-6734-8245es_MX
dc.description.abstractType 2 diabetes mellitus (T2DM) is a chronic condition characterized by impaired insulin sensitivity, resulting in hyperglycemia, dyslipidemia, and other metabolic changes that can damage organs and tissues over time. Obesity is the primary risk factor for the development of T2DM, as it triggers chronic inflammation in adipose tissue, leading to the secretion of adipokines that reduce insulin sensitivity in peripheral tissues. On their part, exosomes, small extracellular vesicles that cells use for intercellular communication, are critical players in fundamental biological processes such as cell growth, metabolism, and inflammation. Changes in the production or composition of exosomes can lead to health issues. In this dissertation, we explore the role of exosomes in cell-to-cell communication and their potential therapeutic use, focusing on the proteomic alterations that occur in exosomes during obesity and their potential functional consequences. The experimental work in this dissertation is divided into three parts. First, we studied the effect of hyperglycemia on cell function in adipocytic and hepatocytic cell lines. Second, we investigated the changes in exosome proteome resulting from obesity and physical training in a mouse model of diet- induced obesity, emphasizing the functional implications of these alterations. Finally, we evaluated the potential therapeutic use of exosomes to deliver bioactive compounds in vitro. This work aims to enhance our understanding of exosome biology and its relevance to health and disease, particularly metabolic disorders such as obesity and T2DM. By shedding light on the functional consequences of altered exosome proteome and exploring the potential of exosomes for therapeutic purposes, this dissertation provides important insights that may pave the way for novel therapeutic approaches for metabolic disorders.es_MX
dc.description.degreeDoctorado en Biotecnologíaes_MX
dc.format.mediumTextoes_MX
dc.identificator2||24||2407||240799es_MX
dc.identifier.citationDonoso Quezada, J. (2023). Exosome-like vesicles in intercellular communication: Investigating the role of exosomal proteins in the pathophysiology of obesity and exploring the potential therapeutic use of exosomes [Unpublished doctoral thesis]. Instituto Tecnológico y de Estudios Superiores de Monterrey. Recuperado de: https://hdl.handle.net/11285/652350es_MX
dc.identifier.cvu995384es_MX
dc.identifier.orcidhttps://orcid.org/0000-0003-2225-3116es_MX
dc.identifier.scopusid57210429337es_MX
dc.identifier.urihttps://hdl.handle.net/11285/652350
dc.language.isoenges_MX
dc.publisherInstituto Tecnológico y de Estudios Superiores de Monterreyes_MX
dc.relation.isFormatOfdraftes_MX
dc.relation.isreferencedbyREPOSITORIO NACIONAL CONACYT
dc.rightsopenAccesses_MX
dc.rights.embargoreasonLa tesis está conformada por datos y manuscritos que próximamente serán enviados para publicación.es_MX
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0es_MX
dc.subject.classificationBIOLOGÍA Y QUÍMICA::CIENCIAS DE LA VIDA::BIOLOGÍA CELULAR::OTRASes_MX
dc.subject.keywordExosomeses_MX
dc.subject.keywordExtracellular vesicleses_MX
dc.subject.keywordType 2 diabeteses_MX
dc.subject.keywordObesityes_MX
dc.subject.keywordDrug deliveryes_MX
dc.subject.keywordNanocarrierses_MX
dc.subject.lcshSciencees_MX
dc.titleExosome-like vesicles in intercellular communication: Investigating the role of exosomal proteins in the pathophysiology of obesity and exploring the potential therapeutic use of exosomes.es_MX
dc.typeTesis de doctorado

Files

Original bundle

Now showing 1 - 3 of 3
Loading...
Thumbnail Image
Name:
DonosoQuezada_TesisEspecialidadpdfa.pdf
Size:
5.65 MB
Format:
Adobe Portable Document Format
Description:
Tesis Doctorado
Loading...
Thumbnail Image
Name:
DonosoQuezada_ActaGradoDeclaracionAutoriapdfa.pdf
Size:
507.04 KB
Format:
Adobe Portable Document Format
Description:
Acta de Grado y Declaración de Autoría
Loading...
Thumbnail Image
Name:
CartaAutorizacionTesis_DonosoJ.pdf
Size:
168.43 KB
Format:
Adobe Portable Document Format
Description:
Carta de autorización

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.3 KB
Format:
Item-specific license agreed upon to submission
Description:
logo

El usuario tiene la obligación de utilizar los servicios y contenidos proporcionados por la Universidad, en particular, los impresos y recursos electrónicos, de conformidad con la legislación vigente y los principios de buena fe y en general usos aceptados, sin contravenir con su realización el orden público, especialmente, en el caso en que, para el adecuado desempeño de su actividad, necesita reproducir, distribuir, comunicar y/o poner a disposición, fragmentos de obras impresas o susceptibles de estar en formato analógico o digital, ya sea en soporte papel o electrónico. Ley 23/2006, de 7 de julio, por la que se modifica el texto revisado de la Ley de Propiedad Intelectual, aprobado

DSpace software copyright © 2002-2025

Licencia