Tesis de maestría

Evaluation of the effect of ellagic acid on muscle differentiation

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Abstract

This thesis investigates the potential impact of ellagic acid (EA), a polyphenol present in various fruits and nuts, on in vitro muscle differentiation using the C2C12 mouse myoblast cell line. Muscle differentiation is a complex process involving specific genes and signaling pathways, and recent interest in natural compounds, including EA, has sparked exploration into their effects on this critical physiological process. The study aims to determine effective and non-cytotoxic concentrations of EA, analyze myotube formation, and evaluate the expression of key differentiation markers at both gene and protein levels. The findings reveal the safety and efficacy of EA at specific concentrations. Morphological, as well as gene and protein expression analyses provide insights into the initiation and progression of myoblast differentiation, emphasizing EA's positive impact on essential markers. This research not only confirms the initial hypothesis but also positions EA as a potent promoter of muscle differentiation, offering potential therapeutic applications for muscle regeneration and disorders. Future directions include exploring EA in pathological muscle conditions and addressing challenges in oral bioavailability through innovative delivery strategies. The ongoing journey into the unknown seeks to deepen our understanding of EA and its broader implications for muscle health.

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https://orcid.org/0000-0003-4399-4618

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El usuario tiene la obligación de utilizar los servicios y contenidos proporcionados por la Universidad, en particular, los impresos y recursos electrónicos, de conformidad con la legislación vigente y los principios de buena fe y en general usos aceptados, sin contravenir con su realización el orden público, especialmente, en el caso en que, para el adecuado desempeño de su actividad, necesita reproducir, distribuir, comunicar y/o poner a disposición, fragmentos de obras impresas o susceptibles de estar en formato analógico o digital, ya sea en soporte papel o electrónico. Ley 23/2006, de 7 de julio, por la que se modifica el texto revisado de la Ley de Propiedad Intelectual, aprobado

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