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Electrospinning Complexly-shaped, Resorbable, Bifurcated Vascular Grafts

dc.creatorChristian Carlos Mendoza Buenrostro
dc.creatorCiro Angel Rodríguez González
dc.date2017
dc.date.accessioned2018-10-19T14:22:10Z
dc.date.available2018-10-19T14:22:10Z
dc.identifier.issn22128271
dc.identifier.doi10.1016/j.procir.2017.04.031
dc.identifier.urihttp://hdl.handle.net/11285/630649
dc.descriptionThe use of vascular grafts is indicated in a wide range of medical treatments. While autologous tissue is the graft of choice in most surgical bypass procedures, the next best option is the use of synthetic vascular grafts. While significant advances have been reported in the use of electrospinning for vascular grafts both at in vitro and in vivo level, most of the work is limited to straight, tubular shapes with uniform diameters. In order to generate resorbable scaffolds with curving and bifurcated tubular shapes with non-uniform diameters, this study proposes combination of directed electrical field and dynamic positioning of electrospun fibers aimed at a custom, 3D printed mandrel. The proposed approach produced a woven membrane of electrospun fibers. In this study, the fibers used were polycaprolactone. They were spun onto a 3D printed (in ABS plastic) bifurcated tubular mandrel. Preliminary mechanical testing of these bifurcated grafts is reported, with maximum indentation force between 0.7 and 2.3 N. In tension tests, the scaffolds showed an average maximum strength of 0.60 MPa (no indexing condition in the B direction) and 1.37 MPa (indexing in the B direction). © 2016 The Authors. Published by Elsevier B.V.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85029703433&doi=10.1016%2fj.procir.2017.04.031&partnerID=40&md5=d8dc6c06e0b10ed2813836073ec93f3a
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceProcedia CIRP
dc.subject3D printers
dc.subjectABS resins
dc.subjectElectrospinning
dc.subjectIndexing (of information)
dc.subjectMechanical testing
dc.subjectScaffolds (biology)
dc.subjectSpinning (fibers)
dc.subjectTensile testing
dc.subjectTissue
dc.subjectTissue engineering
dc.subjectAutologous tissue
dc.subjectBifurcated grafts
dc.subjectElectrospun fibers
dc.subjectMaximum strength
dc.subjectMedical treatment
dc.subjectSynthetic vascular graft
dc.subjectTubular scaffold
dc.subjectVascular grafts
dc.subjectGrafts
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleElectrospinning Complexly-shaped, Resorbable, Bifurcated Vascular Grafts
dc.typeConferencia
dc.identifier.volume65
dc.identifier.startpage207
dc.identifier.endpage212
refterms.dateFOA2018-10-19T14:22:10Z


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