Show simple item record

dc.creatorJosé Gerardo Tamez Peña
dc.date2014
dc.date.accessioned2018-10-19T13:37:39Z
dc.date.available2018-10-19T13:37:39Z
dc.identifier.issn10634584
dc.identifier.doi10.1016/j.joca.2014.03.020
dc.identifier.urihttp://hdl.handle.net/11285/630634
dc.descriptionObjective: Intra-lesional bony overgrowth (BO) identified during or following cartilage repair treatment is being frequently described through subjective reports focusing primarily on incidence. Our objective was to quantify the exact volume of intra-lesional BO at 12 months post-cartilage repair treatment, to determine if a correlation exists between the extent of BO and clinical outcomes, and to visualize and characterize the BO. Design: MRI scans were systematically obtained during a randomized clinical trial for cartilage repair (Stanish etal., 2013) that compared two microfracture-based treatments in 78 patients. Semi-automated morphological segmentation of pre-treatment, 1 and 12 months post-treatment scans utilizing a programmed anatomical atlas for all knee bone and cartilage structures permitted three-dimensional reconstruction, quantitative analysis, as well as qualitative characterization and artistic visualization ofBO. Results: Limited intra-lesional BO representing only 5.8±5.7% of the original debrided cartilage lesion volume was found in 78 patients with available MRIs at 12 months. The majority (80%) of patients had very little BO (<10%). Most occurrences of BO carried either spotty (56.4%) or planar (6.4%) morphological features, and the remaining balance (37.2%) was qualitatively unobservable by eye. Pre-existing BO recurred at 12 months in the same intra-lesional location in 36% of patients. No statistical correlations were found between BO and clinical outcomes. Conclusions: Intra-lesional BO following microfracture-based treatments may not be as severe as previously believed, its incidence is partly explained by pre-existing conditions, and no relationship to clinical outcomes exists at 12 months. Morphologically, observable BO was categorized as comprising either spotty or planar bone. © 2014 Osteoarthritis Research Society International.
dc.languageeng
dc.publisherW.B. Saunders Ltd
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84901829069&doi=10.1016%2fj.joca.2014.03.020&partnerID=40&md5=e87ce09b44b867e874ac3a9c2c17e0ac
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceOsteoarthritis and Cartilage
dc.subjectadult
dc.subjectarticle
dc.subjectbone disease
dc.subjectcartilage
dc.subjectclinical feature
dc.subjectcorrelation analysis
dc.subjectdisease classification
dc.subjectfracture treatment
dc.subjecthuman
dc.subjectimage reconstruction
dc.subjectintralesional bony overgrowth
dc.subjectmicrofracture based cartilage repair
dc.subjectmulticenter study (topic)
dc.subjectnuclear magnetic resonance imaging
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectrandomized controlled trial (topic)
dc.subjectrecurrent disease
dc.subjectthree dimensional imaging
dc.subjectadolescent
dc.subjectarticular cartilage
dc.subjectcallus
dc.subjectchondroplasty
dc.subjectclinical trial
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectevaluation study
dc.subjectfemale
dc.subjectfollow up
dc.subjectKnee Injuries
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectnuclear magnetic resonance imaging
dc.subjectprocedures
dc.subjectrandomized controlled trial
dc.subjectrisk assessment
dc.subjecttime
dc.subjecttreatment outcome
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectArthroplasty, Subchondral
dc.subjectBony Callus
dc.subjectCartilage, Articular
dc.subjectEvaluation Studies as Topic
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectImaging, Three-Dimensional
dc.subjectKnee Injuries
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Assessment
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleQuantitative 3D MRI reveals limited intra-lesional bony overgrowth at1 year after microfracture-based cartilage repair
dc.typeArtículo
dc.identifier.volume22
dc.identifier.issue6
dc.identifier.startpage800
dc.identifier.endpage804
refterms.dateFOA2018-10-19T13:37:39Z


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess