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High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays

dc.creatorVíctor Manuel Treviño Alvarado
dc.creatorHugo Alberto Barrera Saldaña
dc.date2010
dc.date.accessioned2018-10-18T21:51:07Z
dc.date.available2018-10-18T21:51:07Z
dc.identifier.issn426822
dc.identifier.doi10.1016/j.virol.2010.05.011
dc.identifier.urihttp://hdl.handle.net/11285/630510
dc.descriptionWe have developed microarrays with all eight proteins encoded by 13 different human papillomavirus types associated with anogenital cancer (HPV-16, -18, -31, -33, -35, -45, and -53), genital warts (HPV-6 and -11), or skin lesions (HPV-1, -2, -4, and -5). We analyzed the seroprevalence of antibodies in 546 patients, which had either cervical carcinomas, or precursor lesions, or which were asymptomatic. All patient groups contained sera ranging from high reactivity against multiple HPV proteins to low or no reactivity. Computational analyses showed the E7 proteins of carcinogenic HPV types as significantly more reactive in cancer patients compared to asymptomatic individuals and discriminating between cancer and HSIL or LSIL patients. Antibodies against E4 and E5 had the highest seroprevalence but did not exhibit differential reactivity relative to pathology. Our study introduces a new approach to future evaluation of the overall antigenicity of HPV proteins and cross-reaction between homologous proteins. © 2010 Elsevier Inc.
dc.languageeng
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77955514666&doi=10.1016%2fj.virol.2010.05.011&partnerID=40&md5=630f9afd601bb2258b2b67ad20523b9f
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceVirology
dc.subjectmonoclonal antibody
dc.subjectprotein E4
dc.subjectprotein E5
dc.subjectunclassified drug
dc.subjectvirus protein
dc.subjectarticle
dc.subjectcondyloma acuminatum
dc.subjectcontrolled study
dc.subjectcross reaction
dc.subjecthuman
dc.subjectHuman papillomavirus type 1
dc.subjectHuman papillomavirus type 11
dc.subjectHuman papillomavirus type 16
dc.subjectHuman papillomavirus type 18
dc.subjecthuman papillomavirus type 2
dc.subjectHuman papillomavirus type 31
dc.subjectHuman papillomavirus type 35
dc.subjectHuman papillomavirus type 4
dc.subjectHuman papillomavirus type 45
dc.subjectHuman papillomavirus type 53
dc.subjectHuman papillomavirus type 6
dc.subjecthumoral immunity
dc.subjectimmune response
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectprotein microarray
dc.subjectproteomics
dc.subjectseroprevalence
dc.subjectWart virus
dc.subjectAdenocarcinoma
dc.subjectAdult
dc.subjectAlphapapillomavirus
dc.subjectAntibodies, Viral
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectGenome, Viral
dc.subjectHumans
dc.subjectNeoplasms, Squamous Cell
dc.subjectPapillomavirus Infections
dc.subjectProtein Array Analysis
dc.subjectUterine Cervical Neoplasms
dc.subjectHuman papillomavirus
dc.subjectHuman papillomavirus types
dc.subjectPapillomaviridae
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleHigh-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays
dc.typeArtículo
dc.identifier.volume405
dc.identifier.issue1
dc.identifier.startpage31
dc.identifier.endpage40
refterms.dateFOA2018-10-18T21:51:07Z


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