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The effect of anterior cruciate ligament injury on bone curvature: Exploratory analysis in the KANON trial

dc.creatorJosé Gerardo Tamez Peña
dc.date2014
dc.date.accessioned2018-10-18T21:50:59Z
dc.date.available2018-10-18T21:50:59Z
dc.identifier.issn10634584
dc.identifier.doi10.1016/j.joca.2014.05.014
dc.identifier.urihttp://hdl.handle.net/11285/630477
dc.descriptionObjective: Investigate the 5-year longitudinal changes in bone curvature after acute anterior cruciate ligament (ACL) injury, and identify predictors of such changes. Methods: In the KANON-trial (ISRCTN 84752559), 111/121 young active adults with an acute ACL tear to a previously un-injured knee had serial 1.5T MR images from baseline (within 5 weeks from injury) to 5 years after injury. Of these, 86 had ACL reconstruction (ACLR) performed early or delayed, 25 were treated with rehabilitation alone. Measures of articulating bone curvature were obtained from computer-assisted segmentation of MR images. Curvature (mm-1) was determined for femur, tibia, medial/lateral femur, trochlea, medial/lateral tibia. Age, sex, treatment, BMI, meniscal injury, osteochondral fracture on baseline MR images were tested for association. Results: Over 5 years, curvature decreased in each region (P<0.001) suggesting flattening of convex shapes and increased concavity of concave shapes. A higher BMI was associated with flattening of the femur (P=0.03), trochlea (P=0.007) and increasing concavity of the lateral tibia (LT) (P=0.011). ACLR, compared to rehabilitation alone, was associated with flatter curvature in the femur (P<0.001), medial femoral condyle (P=0.006) and trochlea (P=0.003). Any meniscal injury at baseline was associated with a more flattened curvature in the femur (P=0.038), trochlea (P=0.039), lateral femoral condyle (P=0.034) and increasing concavity of the LT (P=0.048). Conclusion: ACL injury is associated with significant changes in articulating bone curvature over a 5 year period. Higher BMI, baseline meniscal injury and undergoing ACL reconstruction (as distinct from undergoing rehabilitation alone) are all associated with flattening of the articulating bone. © 2014 Osteoarthritis Research Society International.
dc.languageeng
dc.publisherW.B. Saunders Ltd
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84903761170&doi=10.1016%2fj.joca.2014.05.014&partnerID=40&md5=e0abcbd2c5ed47930d809c96ee5d1887
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceOsteoarthritis and Cartilage
dc.subjectadult
dc.subjectage
dc.subjectanterior cruciate ligament injury
dc.subjectarticle
dc.subjectbody mass
dc.subjectbone curvature
dc.subjectexploratory research
dc.subjectfemale
dc.subjectfemur
dc.subjectfemur condyle
dc.subjectfracture
dc.subjecthuman
dc.subjectknee meniscus rupture
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmusculoskeletal system parameters
dc.subjectnuclear magnetic resonance imaging
dc.subjectnuclear magnetic resonance scanner
dc.subjectosteochondral fracture
dc.subjectpriority journal
dc.subjectrandomized controlled trial (topic)
dc.subjectsex
dc.subjecttibia
dc.subjectadolescent
dc.subjectanterior cruciate ligament
dc.subjectanterior cruciate ligament reconstruction
dc.subjectcomplication
dc.subjectcontrolled study
dc.subjectinjuries
dc.subjectKnee Injuries
dc.subjectpathology
dc.subjectphysiotherapy
dc.subjectrandomized controlled trial
dc.subjecttime
dc.subjecttreatment outcome
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnterior Cruciate Ligament
dc.subjectAnterior Cruciate Ligament Reconstruction
dc.subjectBody Mass Index
dc.subjectFemale
dc.subjectFemur
dc.subjectHumans
dc.subjectKnee Injuries
dc.subjectLongitudinal Studies
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPhysical Therapy Modalities
dc.subjectTibia
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.subjectYoung Adult
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleThe effect of anterior cruciate ligament injury on bone curvature: Exploratory analysis in the KANON trial
dc.typeArtículo
dc.identifier.volume22
dc.identifier.issue7
dc.identifier.startpage959
dc.identifier.endpage968
refterms.dateFOA2018-10-18T21:50:59Z


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