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Relationship between irisin concentration and serum cytokines in mother and newborn

dc.creatorEstibalitz Laresgoiti Servitje
dc.creatorGerardo de Jesús García Rivas
dc.date2016
dc.date.accessioned2018-10-18T21:22:02Z
dc.date.available2018-10-18T21:22:02Z
dc.identifier.issn19326203
dc.identifier.doi10.1371/journal.pone.0165229
dc.identifier.urihttp://hdl.handle.net/11285/630461
dc.descriptionIntroduction: Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy. However, the regulation of circulating irisin and its relationship with other cytokines has not been assessed thus far in pregnant women and their offspring. Objective: The aim of this study was to evaluate differences in irisin and cytokine concentrations between women at the end of pregnancy and their offspring, as well as the relationship between maternal and newborn irisin and maternal and newborn biomarkers. Methods: Twenty-eight mother/newborn pairs were included in this study. The following biomarkers were evaluated in maternal venous and arterial umbilical cord blood samples: irisin, 27 cytokine panel, total antioxidant capacity (TAC), total plasma protein, and free fatty acid concentration. Results: The newborns had significantly lower irisin concentrations compared to their mothers (p = 0.03), but this difference was present only in babies born from mothers without labor prior to cesarean section delivery (p = 0.01). No significant differences in maternal and newborn irisin concentrations were found between diabetic and non-diabetic mothers or between overweight/obese and normal weight mothers. A significant positive correlation was found between TAC level and irisin concentration in newborns. Maternal and newborn interleukin (IL)-1β, IL-1RA, IL-5, IL-7, and interferon gamma-induced protein (IP)-10 levels were significantly positively correlated with irisin concentrations in both study groups. In addition, maternal IL1β, IL-5, IL-7, and IP-10 levels positively predicted maternal irisin concentrations. Furthermore, arterial cord blood TAC and IL-1β and IL1-RA levels positively predicted newborn irisin concentrations. Multiple regression analyses showed that maternal IL-13 negatively predicted offspring irisin levels (p = 0.03) and that maternal IL-1β positively predicted newborn irisin concentrations (p = 0.046). Conclusion: No evidence was found that serum irisin concentrations in mothers at pregnancy termination or those of their newborns correlated with maternal body mass index, the presence of diabetes mellitus, or free fatty acid levels. However, the results of this study indicated that cytokines might predict irisin concentration in mothers and their offspring, although interactions between irisin levels during pregnancy and the newborn have not yet been fully elucidated. © 2016 Hernandez-Trejo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.languageeng
dc.publisherPublic Library of Science
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84994493265&doi=10.1371%2fjournal.pone.0165229&partnerID=40&md5=f0e8db5a1287fffc3f0d018c044bdd32
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePLoS ONE
dc.subjectcytokine
dc.subjectfatty acid
dc.subjectgamma interferon inducible protein 10
dc.subjectinterleukin 1 receptor blocking agent
dc.subjectinterleukin 1beta
dc.subjectinterleukin 5
dc.subjectinterleukin 7
dc.subjectirisin
dc.subjectplasma protein
dc.subjectantioxidant
dc.subjectbiological marker
dc.subjectCXCL10 protein, human
dc.subjectcytokine
dc.subjectfatty acid
dc.subjectfibronectin
dc.subjectFNDC5 protein, human
dc.subjectgamma interferon inducible protein 10
dc.subjectinterleukin derivative
dc.subjectadolescent
dc.subjectadult
dc.subjectarterial blood
dc.subjectArticle
dc.subjectblood sampling
dc.subjectbody weight
dc.subjectcesarean section
dc.subjectchemical parameters
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcytokine blood level
dc.subjectfemale
dc.subjectgamma interferon inducible protein 10 blood level
dc.subjecthormone blood level
dc.subjecthormone determination
dc.subjecthuman
dc.subjectinterleukin 1beta blood level
dc.subjectinterleukin 5 blood level
dc.subjectinterleukin 7 blood level
dc.subjectirisin blood level
dc.subjectlabor
dc.subjectmale
dc.subjectmaternal blood
dc.subjectnewborn
dc.subjectobesity
dc.subjectperinatal period
dc.subjectprediction
dc.subjectpregnancy diabetes mellitus
dc.subjectprogeny
dc.subjectprotein blood level
dc.subjectprotein determination
dc.subjecttotal antioxidant capacity
dc.subjectumbilical cord blood
dc.subjectvenous blood
dc.subjectblood
dc.subjectbody mass
dc.subjectfetus blood
dc.subjectmetabolism
dc.subjectmother
dc.subjectmultivariate analysis
dc.subjectpregnancy
dc.subjectstatistical model
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntioxidants
dc.subjectBiomarkers
dc.subjectBody Mass Index
dc.subjectChemokine CXCL10
dc.subjectCytokines
dc.subjectDiabetes, Gestational
dc.subjectFatty Acids
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectFibronectins
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectInterleukins
dc.subjectLinear Models
dc.subjectMothers
dc.subjectMultivariate Analysis
dc.subjectPregnancy
dc.subjectYoung Adult
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleRelationship between irisin concentration and serum cytokines in mother and newborn
dc.typeArtículo
dc.identifier.volume11
dc.identifier.issue11
refterms.dateFOA2018-10-18T21:22:02Z


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