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The impact of LEP G-2548A and LEPR Gln223Arg polymorphisms on adiposity, leptin, and leptin-receptor serum levels in a Mexican Mestizo population

dc.creatorLizeth Sánchez López
dc.date2015
dc.date.accessioned2018-10-18T20:12:58Z
dc.date.available2018-10-18T20:12:58Z
dc.identifier.issn23146133
dc.identifier.doi10.1155/2015/539408
dc.identifier.urihttp://hdl.handle.net/11285/630344
dc.descriptionThe polymorphisms in leptin (LEP G-2548A) and leptin-receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others. The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin-receptor (sLeptin-receptor) serum concentrations as well as inflammation markers. We included 382 adults originally from Western Mexico. They were genotyped by PCR-RFLP. Obese individuals showed higher sLeptin (58.2 ± 31.35 ng/mL) but lower sLeptin-receptor (12.6 ± 3.74 ng/mL) levels than normal weight ones (17.6 ± 14.62 ng/mL, 17.4 ± 4.62 ng/mL, resp.), P < 0.001. Obese subjects carriers of Arg/Arg genotype had more (P = 0.016) sLeptin-receptor (14.7 ± 4.96 ng/mL) and less (P = 0.004) sLeptin (44.0 ± 28.12 ng/mL) levels than Gln/Gln genotype (11.0 ± 2.92 ng/mL, 80.3 ± 33.24 ng/mL, resp.). Body fat mass was lower (P from 0.003 to 0.045) for A/A (36.5 % ± 6.80) or Arg/Arg (36.8 % ± 6.82) genotypes with respect to G/G (41.3 % ± 5.52) and G/A (41.6 % ± 5.61) or Gln/Gln (43.7 % ± 4.74) and Gln/Arg (41.0 % ± 5.52) genotypes carriers. Our results suggest that LEP-2548A and LEPR 223Arg could be genetic markers of less body fat mass accumulation in obese subjects from Western Mexico. © 2015 Efraín Chavarria-Avila et al.
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84930618830&doi=10.1155%2f2015%2f539408&partnerID=40&md5=56ed52aea3e26a1190bd3e3ef2bfee8e
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBioMed Research International
dc.subjectarginine
dc.subjectleptin
dc.subjectleptin receptor
dc.subjectleptin
dc.subjectleptin receptor
dc.subjectleptin receptor, human
dc.subjectadult
dc.subjectArticle
dc.subjectbody fat
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectfat mass
dc.subjectfemale
dc.subjectgenetic marker
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjectheterozygote
dc.subjecthuman
dc.subjectlipid metabolism
dc.subjectmale
dc.subjectMexican
dc.subjectobesity
dc.subjectpopulation research
dc.subjectprotein blood level
dc.subjectblood
dc.subjectbody mass
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectMexican American
dc.subjectMexico
dc.subjectmiddle aged
dc.subjectobesity
dc.subjectpathology
dc.subjectsingle nucleotide polymorphism
dc.subjectAdiposity
dc.subjectAdult
dc.subjectBody Mass Index
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHumans
dc.subjectLeptin
dc.subjectLipid Metabolism
dc.subjectMale
dc.subjectMexican Americans
dc.subjectMexico
dc.subjectMiddle Aged
dc.subjectObesity
dc.subjectPolymorphism, Single Nucleotide
dc.subjectReceptors, Leptin
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleThe impact of LEP G-2548A and LEPR Gln223Arg polymorphisms on adiposity, leptin, and leptin-receptor serum levels in a Mexican Mestizo population
dc.typeArtículo
dc.identifier.volume2015
refterms.dateFOA2018-10-18T20:12:58Z


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