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dc.creatorJacobo Ayala Aguilar
dc.date2017
dc.date.accessioned2018-10-18T20:12:55Z
dc.date.available2018-10-18T20:12:55Z
dc.identifier.issn12019712
dc.identifier.doi10.1016/j.ijid.2017.02.005
dc.identifier.urihttp://hdl.handle.net/11285/630332
dc.descriptionObjective Introduction of pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes substantially decreased invasive (IPD) and non-invasive pneumococcal diseases (NIPD) but it was accompanied by non-vaccine type replacement disease. After 9 years of introduction of PCV in Mexico, we analyze the evidence of the indirect effects on IPD and NIPD serotype distribution among groups not targeted to receive the vaccine. Methods From January 2000 to December 2014, pneumococcal strains isolated from IPD and NIPD cases from patients ≥5 years of age from participant hospitals of the SIREVA II (Sistema Regional de Vacunas) network were serotyped. A regression analysis was performed considering year and proportion of serotypes included in the different vaccine formulations (PCV7, PCV10 and PCV13). The slope was obtained for each regression line and their correspondent p-value. The proportion of each serotype in the pre-PCV7 and post-PCV7 periods was evaluated by χ2 test. Results From a total of 1147 pneumococcal strains recovered, 570 corresponded to the pre-PCV7 and 577 to the post-PCV7 periods. The proportion of vaccine serotypes included in the three PCV formulations decreased by 2.4, 2.6 and 1.3%, respectively per year during the study period. A significant increase of serotype 19A was observed in the post-vaccine period in all age groups. Conclusions A percentage of annual decline of serotypes causing IPD and NIPD included in PCV was detected among groups not targeted to receive the vaccine, probably due to herd effect. Considering pneumococcal serotype distribution is a dynamic process, we highlight the importance of surveillance programs. © 2017 The Author(s)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016256867&doi=10.1016%2fj.ijid.2017.02.005&partnerID=40&md5=e838531b785d12ad6b6096b7b0a5581b
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceInternational Journal of Infectious Diseases
dc.subjectPneumococcus vaccine
dc.subjectPneumococcus vaccine
dc.subjectvaccine
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectbacterial strain
dc.subjectbacterium isolate
dc.subjectchild
dc.subjectdrug formulation
dc.subjecthuman
dc.subjectMexico
dc.subjectnonhuman
dc.subjectpneumococcal infection
dc.subjectserotype
dc.subjectStreptococcus infection
dc.subjectStreptococcus pneumoniae
dc.subjecttrend study
dc.subjectclassification
dc.subjectfemale
dc.subjecthospital
dc.subjectisolation and purification
dc.subjectmale
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectpneumococcal infection
dc.subjectserotyping
dc.subjectStreptococcus pneumoniae
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectHospitals
dc.subjectHumans
dc.subjectMale
dc.subjectMexico
dc.subjectMiddle Aged
dc.subjectPneumococcal Infections
dc.subjectPneumococcal Vaccines
dc.subjectSerotyping
dc.subjectStreptococcus pneumoniae
dc.subjectVaccines, Conjugate
dc.subjectYoung Adult
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleChanging trends in serotypes of S. pneumoniae isolates causing invasive and non-invasive diseases in unvaccinated population in Mexico (2000-2014)
dc.typeArtículo
dc.identifier.volume58
dc.identifier.startpage1
dc.identifier.endpage7
refterms.dateFOA2018-10-18T20:12:55Z


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