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Topical anti-inflammatory effects of isorhamnetin glycosides isolated from opuntia ficus-indica

dc.creatorMarilena Antunes Ricardo
dc.creatorSergio Román Othón Serna Saldívar
dc.creatorJanet Alejandra Gutiérrez Uribe
dc.date2015
dc.date.accessioned2018-10-18T19:54:20Z
dc.date.available2018-10-18T19:54:20Z
dc.identifier.issn23146133
dc.identifier.doi10.1155/2015/847320
dc.identifier.urihttp://hdl.handle.net/11285/630288
dc.descriptionOpuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro (73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema (77.4 ± 5.7 %) equating the indomethacin effects (69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient. © 2015 Marilena Antunes-Ricardo et al.
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84925340747&doi=10.1155%2f2015%2f847320&partnerID=40&md5=5c97b68f34d11c67a6bdca1e3bcb6535
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceBioMed Research International
dc.subjectantiinflammatory agent
dc.subjectcyclooxygenase 2
dc.subjectflavonoid glycoside
dc.subjectindometacin
dc.subjectinterleukin 6
dc.subjectisorhamnetin
dc.subjectisorhamnetin glucosyl pentoside
dc.subjectisorhamnetin glucosyl rhamnoside
dc.subjectisorhamnetin glucosyl rhamnosyl pentoside
dc.subjectisorhamnetin glucosyl rhamnosyl rhamnoside
dc.subjectisorhamnetin glycoside derivative
dc.subjectnitric oxide
dc.subjectOpuntia ficus indica extract
dc.subjectplant extract
dc.subjecttumor necrosis factor alpha
dc.subjectunclassified drug
dc.subject3-methylquercetin
dc.subjectantiinflammatory agent
dc.subjectcytokine
dc.subjectglycoside
dc.subjectplant extract
dc.subjectquercetin
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantiinflammatory activity
dc.subjectArticle
dc.subjectcell proliferation
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdrug identification
dc.subjectear edema
dc.subjectenzyme activity
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectmacrophage
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouse
dc.subjectnonhuman
dc.subjectOpuntia ficus-indica
dc.subjectrat
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectchemistry
dc.subjectdose response
dc.subjectimmunology
dc.subjectOpuntia
dc.subjectOtitis Externa
dc.subjecttreatment outcome
dc.subjectWistar rat
dc.subjectOpuntia ficus-indica
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectCytokines
dc.subjectDose-Response Relationship, Drug
dc.subjectGlycosides
dc.subjectMale
dc.subjectOpuntia
dc.subjectOtitis Externa
dc.subjectPlant Extracts
dc.subjectQuercetin
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTreatment Outcome
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleTopical anti-inflammatory effects of isorhamnetin glycosides isolated from opuntia ficus-indica
dc.typeArtículo
dc.identifier.volume2015
refterms.dateFOA2018-10-18T19:54:20Z


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