dc.creator | Marilena Antunes Ricardo | |
dc.creator | Sergio Román Othón Serna Saldívar | |
dc.creator | Janet Alejandra Gutiérrez Uribe | |
dc.date | 2015 | |
dc.date.accessioned | 2018-10-18T19:54:20Z | |
dc.date.available | 2018-10-18T19:54:20Z | |
dc.identifier.issn | 23146133 | |
dc.identifier.doi | 10.1155/2015/847320 | |
dc.identifier.uri | http://hdl.handle.net/11285/630288 | |
dc.description | Opuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro (73.5 ± 4.8 % and 68.7 ± 5.0 %, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema (77.4 ± 5.7 %) equating the indomethacin effects (69.5 ± 5.3 %). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient. © 2015 Marilena Antunes-Ricardo et al. | |
dc.language | eng | |
dc.publisher | Hindawi Publishing Corporation | |
dc.relation | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925340747&doi=10.1155%2f2015%2f847320&partnerID=40&md5=5c97b68f34d11c67a6bdca1e3bcb6535 | |
dc.relation | Investigadores | |
dc.relation | Estudiantes | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.source | BioMed Research International | |
dc.subject | antiinflammatory agent | |
dc.subject | cyclooxygenase 2 | |
dc.subject | flavonoid glycoside | |
dc.subject | indometacin | |
dc.subject | interleukin 6 | |
dc.subject | isorhamnetin | |
dc.subject | isorhamnetin glucosyl pentoside | |
dc.subject | isorhamnetin glucosyl rhamnoside | |
dc.subject | isorhamnetin glucosyl rhamnosyl pentoside | |
dc.subject | isorhamnetin glucosyl rhamnosyl rhamnoside | |
dc.subject | isorhamnetin glycoside derivative | |
dc.subject | nitric oxide | |
dc.subject | Opuntia ficus indica extract | |
dc.subject | plant extract | |
dc.subject | tumor necrosis factor alpha | |
dc.subject | unclassified drug | |
dc.subject | 3-methylquercetin | |
dc.subject | antiinflammatory agent | |
dc.subject | cytokine | |
dc.subject | glycoside | |
dc.subject | plant extract | |
dc.subject | quercetin | |
dc.subject | animal cell | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | antiinflammatory activity | |
dc.subject | Article | |
dc.subject | cell proliferation | |
dc.subject | cell viability | |
dc.subject | controlled study | |
dc.subject | cytokine production | |
dc.subject | drug identification | |
dc.subject | ear edema | |
dc.subject | enzyme activity | |
dc.subject | in vitro study | |
dc.subject | in vivo study | |
dc.subject | macrophage | |
dc.subject | male | |
dc.subject | medicinal plant | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | Opuntia ficus-indica | |
dc.subject | rat | |
dc.subject | analogs and derivatives | |
dc.subject | animal | |
dc.subject | chemistry | |
dc.subject | dose response | |
dc.subject | immunology | |
dc.subject | Opuntia | |
dc.subject | Otitis Externa | |
dc.subject | treatment outcome | |
dc.subject | Wistar rat | |
dc.subject | Opuntia ficus-indica | |
dc.subject | Animals | |
dc.subject | Anti-Inflammatory Agents | |
dc.subject | Cytokines | |
dc.subject | Dose-Response Relationship, Drug | |
dc.subject | Glycosides | |
dc.subject | Male | |
dc.subject | Opuntia | |
dc.subject | Otitis Externa | |
dc.subject | Plant Extracts | |
dc.subject | Quercetin | |
dc.subject | Rats | |
dc.subject | Rats, Wistar | |
dc.subject | Treatment Outcome | |
dc.subject.classification | 7 INGENIERÍA Y TECNOLOGÍA | |
dc.title | Topical anti-inflammatory effects of isorhamnetin glycosides isolated from opuntia ficus-indica | |
dc.type | Artículo | |
dc.identifier.volume | 2015 | |
refterms.dateFOA | 2018-10-18T19:54:20Z | |