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dc.contributor.authorValdéz García, Jorge E.en
dc.contributor.authorLozano Ramirez, Juan Fen
dc.contributor.authorZavala, Judithen
dc.date.accessioned2016-06-14T19:19:29Z
dc.date.available2016-06-14T19:19:29Z
dc.date.issued04/02/2015
dc.identifier.otherBMC Research Notes. 2015 Feb 04;8(1):28
dc.identifier.urihttp://dx.doi.org/10.1186/s13104-015-0995-1
dc.identifier.urihttp://hdl.handle.net/11285/613130
dc.description.abstractAbstract Background Corneal endothelium engineering is focused in producing transplantable cell sheets to overcome the shortage of corneal graft tissue donors for the treatment of corneal blindness. For this purpose, the use of a proper animal model plays a key role. Corneal parameters of White New Zealand rabbits such as endothelial cell density, central corneal thickness, and corneal diameter decrease with age, similarly as in humans. However, as opposed to humans, they retain the ability to restore their corneal endothelium after injury. Therefore, they are considered as an inappropriate corneal endothelial wound healing model. Findings Here we analyze the corneal endothelium mitotic ability of White New Zealand rabbits aged 3, 6, 12 and 18 months, 36 and 72 hours after thermal injury. The highest mitotic activity was observed in the 3-month rabbits 36 h after wounding. Rabbits of 12 months registered decreased mitotic activity and those of 18 months did not show mitotic activity 72 h after injury. Conclusions These results propose that rabbits of 18 months represent a suitable model for human corneal endothelium engineering research.
dc.language.isoengen
dc.publisherSpringer Openen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322652/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleAdult white New Zealand rabbit as suitable model for corneal endothelial engineeringen
dc.typeArtículo / Articleen
dc.identifier.pmcidPMC4322652
dc.rights.holderValdez García et al.; licensee BioMed Central.
dc.date.updated2016-06-01T12:19:28Z
dc.subject.keywordCorneaen
dc.subject.keywordCorneal engineeringen
dc.subject.keywordEndotheliumen
dc.subject.keywordMitosisen
dc.subject.keywordNew Zealand rabbiten
dc.subject.disciplineCiencias de la Salud / Health Sciences
refterms.dateFOA2018-03-17T08:15:39Z
html.description.abstractAbstract Background Corneal endothelium engineering is focused in producing transplantable cell sheets to overcome the shortage of corneal graft tissue donors for the treatment of corneal blindness. For this purpose, the use of a proper animal model plays a key role. Corneal parameters of White New Zealand rabbits such as endothelial cell density, central corneal thickness, and corneal diameter decrease with age, similarly as in humans. However, as opposed to humans, they retain the ability to restore their corneal endothelium after injury. Therefore, they are considered as an inappropriate corneal endothelial wound healing model. Findings Here we analyze the corneal endothelium mitotic ability of White New Zealand rabbits aged 3, 6, 12 and 18 months, 36 and 72 hours after thermal injury. The highest mitotic activity was observed in the 3-month rabbits 36 h after wounding. Rabbits of 12 months registered decreased mitotic activity and those of 18 months did not show mitotic activity 72 h after injury. Conclusions These results propose that rabbits of 18 months represent a suitable model for human corneal endothelium engineering research.


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