Anti-neoplastic properties of black bean flavonoids in diffuse large B cell lymphoma
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Abstract
In general terms, lymphoma, is the way of designating the set of tumors that develop in the lymphoreticular system, [1].The most frequent of the lymphomas is the diffuse large B cell lymphoma B (DLBCL), with a frequency of 30 % in the USA, near 50 % in Mexico [2,3].Some of the drugs that form part of the chemotherapy to treat the DLBCL comefrom natural sources as plants i.e. alkaloids of the vinca or from microorganisms like the estreptomyces peucetycuswhere Doxorrubicine is obtained. Doxorubicin is an anthracycline and its effect is a direct damage in the DNA helix without possibilities of restoring, Doxorubicin is considered as cornerstone intreatment of lymphoma patients[4].The chemotherapy withoutanthracyclineshasobtainedpoor resultsin the survival[5]. Thus, it is necessary to look for new options that could increase the rates of response and the survival of the patientsbesides doxorubicin. There are several compounds in plants and fruits of our flora, which have the property of being anticancerous such as flavonoids.