Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551014
Pertenecen a esta colección Tesis y Trabajos de grado de los Doctorados correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Platelets contribute to hemostasis, thrombosis, and allergic airway inflammation via Munc13-4-dependent secretion(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2018-11-01) Cárdenas Cantú, Eduardo Israel; CARDENAS CANTU, EDUARDO ISRAEL; 510470; Scott, Sean p; Adachi, Roberto; Vahid Afshar-Kharghan; Rocío Ortiz López; María Teresa González Garza y BarrónWith over 200 million affected individuals, asthma is the most common chronic respiratory disease in the world. One old observation that begs an explanation is the relationship between platelets, their activation, and the manifestations of asthma. Althoug
- Self-Assembly behavior of amphiphilic janus dendrimers in water: a combined experimental and coarse-grained molecular dynamics simulation approach(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2018-05-14) Elizondo García, Mariana Estefanía; ELIZONDO GARCIA, MARIANA ESTEFANIA; 373696; Valencia Gallegos, Jesús Ángel; Videa Vargas, Marcelo Fernando; Gutiérrez Uribe, Janet Alejandra; González Nilo, Fernando Danilo; Cortéz Ramírez, JorgeAmphiphilic Janus dendrimers (JDs) are repetitively branched molecules with hydrophilic and hydrophobic components that self-assemble in water to form a variety of morphologies, including vesicles analogous to liposomes with potential pharmaceutical and medical application. To date, the self-assembly of JDs has not been fully investigated thus it is important to gain insight into its mechanism and dependence on JDs’ molecular structure.
- Controlled drug delivery strategies: Advances on the synthesis and molecular dynamics of dendrimers, and optimization of liposomes preparation by Dual Asymmetric Centrifugation(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2017-12-01) Sampogna Mireles, Diana; SAMPOGNA MIRELES, DIANA; 386013; Valencia Gallegos, Jesús Ángel; Guitiérrez Uribe, Janet Alejandra; Elizondo Martínez, Perla; Hernández Hernández, José Ascención; Aguilar Jimenéz, Oscar AlejandroIn early phase of drug development, New Chemical Entities (NCEs) are used as highly active drugs, with limited availability, and high cost. This study presents two alternatives of drug delivery systems, site-specific dendrimers and liposomes, with potenti
- Novel bioengineering strategies for the recovery and purification of PEGylated lysozyme conjugates: in situ ATPS and affinity chromatography(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2017-07-13) Mejía Manzano, Luis Alberto; Mejía Manzano, Luis Alberto; 375359; Rito Palomares, Marco Antonio; Mayolo Deloisa, Karla Patricia; González Valdez, José Guillermo; Asenjo de Leuze, Juan A.; Parra Saldívar, RobertoPEGylation is the modification of therapeutic proteins with polyethylene glycol (PEG) with the goal of improving their bioavailability and effectivity in the organism. During the PEGylation process, proteins with different degrees of PEGylation and positi